Scientist Tim Ledford creates a mind-reading machine and pushes two couples he knows to test it. Something goes awry. Instead of reading each other's minds, his subjects have switched places. The men's minds are in the women's bodies, and visa versa.

While Tim tries to figure out what went wrong, the couples are forced to go on with their lives as different people. Each learns a lot about the other gender in the process, and even more about the person they thought they knew well before swapping bodies with them.